Protein Details: Cyclic nucleotide-gated ion channel 18

Protein ID

ICDB_Pro_1553

Protein Name

Cyclic nucleotide-gated ion channel 18

Gene Name

CNGC18 At5g14870 T9L3_170

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

706 amino acids

AlphaFoldDB

AF-Q9LEQ3-F1-model_v4.pdb

Function

Cyclic nucleotide-gated ion channel required for directional pollen tube growth into the transmitting tract. Acts as a Ca(2+)-permeable divalent cation-selective channel inhibited by either lanthanum or gadolinium. Regulated by CPK32 to mediate Ca(2+) transport across the plasma membrane in response to Ca(2+) oscillation.

Sequence

MNKIRSLRCLLPETITSASTAASNRGSDGSQFSVLWRHQILDPDSNIVTYWNHVFLITSILALFLDPFYFYVPYVGGPACLSIDISLAATVTFFRTVADIFHLLHIFMKFRTAFVARSSRVFGRGELVMDSREIAMRYLKTDFLIDVAAMLPLPQLVIWLVIPAATNGTANHANSTLALIVLVQYIPRSFIIFPLNQRIIKTTGFIAKTAWAGAAYNLLLYILASHVLGAMWYLSSIGRQFSCWSNVCKKDNALRVLDCLPSFLDCKSLEQPERQYWQNVTQVLSHCDATSSTTNFKFGMFAEAFTTQVATTDFVSKYLYCLWWGLRNLSSYGQNITTSVYLGETLFCITICIFGLILFTLLIGNMQSSLQSMSVRVEEWRVKRRDTEEWMRHRQLPPELQERVRRFVQYKWLATRGVDEESILHSLPTDLRREIQRHLCLSLVRRVPFFSQMDDQLLDAICGCLVSSLSTAGTYIFREGDPVNEMLFVIRGQIESSTTNGGRSGFFNSTTLRPGDFCGEELLTWALMPNSTLNLPSSTRSVRALSEVEAFALSAEDLKFVAHQFKRLQSKKLQHAFRYYSHQWRAWGACFVQSAWRRYKRRKLAKELSLHESSGYYYPDETGYNEEDEETREYYYGSDEEGGSMDNTNLGATILASKFAANTRRGTNQKASSSSTGKKDGSSTSLKMPQLFKPDEPDFSIDKEDV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 449..579; /ligand="a nucleoside 3,5-cyclic phosphate"; BINDING 520; /ligand="a nucleoside 3,5-cyclic phosphate"

Disease

Location

Expressed in pollen grains. Not detected in leaves, roots or root hairs. {ECO:0000269|PubMed:17726111}.

DOI ID

10.1038/35048507; 10.1111/tpj.13415; 10.1104/pp.126.4.1646; 10.1073/pnas.0701781104; 10.1093/mp/sst174; 10.1093/mp/sst125; 10.1073/pnas.1524629113

RefSeq

NP_196991.1